Following widespread use of the vaccine there have been extremely rare reports of blood clots in combination with low level of blood platelets. Get urgent medical attention if you get symptoms of a severe allergic reaction. 0000005805 00000 n Tell your doctor, pharmacist or nurse before vaccination: If you are not sure if any of the above applies to you, talk to your doctor, pharmacist or nurse before you are given the vaccine. b t@f&!+:eez8YY8.j 7 COVID-19 Vaccine AstraZeneca stimulates the bodys natural defences (immune system). This medicine contains a very small amount of alcohol (2 mg of alcohol (ethanol) per dose of 0.5 ml). Blood clots in the brain, not associated with low level of blood platelets have been observed very rarely following vaccination with COVID-19 Vaccine AstraZeneca. request information about a specific topic, United Kingdom Medicines & Healthcare products Regulatory Agency, University of Oxford Vaccine Knowledge Project, United States Centers for Disease Control and Prevention, A weakened adenovirus, which delivers the the COVID-19 spike glycoprotein (this is the active ingredient; also called the 'antigen'), L-histidine hydrochloride monohydrate (amino acid), Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial (, A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity (, Adenoviral vectors are the new COVID-19 vaccine front-runners. <>/Metadata 30 0 R>> x]n@@eH%/Vu1]}sn\H6:ypen^mVU}m)QmB9ciMeT{ed#NtQwv/ ,6aYmk}*Oko8/q1(z h^ONc! 0000004159 00000 n This means that a COVID-19 vaccine cannot make you sick with COVID-19. Vaccine Excipient Summary Excipients Included in U.S. 0000004413 00000 n 0000055862 00000 n *Recombinant, replication-deficient chimpanzee adenovirus vector encoding the SARS-CoV-2 Spike glycoprotein. endstream endobj 73 0 obj <>/Font<>/ProcSet[/PDF /Text /ImageB /ImageC /ImageI]/XObject<>>>/Rotate 0/Type/Page>> endobj 74 0 obj <> stream 0000088968 00000 n EDTA is not listed as an ingredient in the Johnson &. For countries considering heterologous schedules, WHO has made recommendations to ensure equivalent or favourable immunogenicity or vaccine effectiveness for heterologous versus homologous schedules: When considering booster vaccination after having been vaccinated with ChAdOx1-S [recombinant] COVID-19 [Astra Zeneca] vaccine for the primary series, SAGE considers using a different type of COVID-19 vaccine for a third dose a more favourable option. hb```b``9 |Abl,=@00M(P~. dwS(V"2G %[CA+|}e9;(al-U c9.3T@k w endstream endobj 819 0 obj <>/Metadata 27 0 R/Outlines 44 0 R/Pages 815 0 R/StructTreeRoot 48 0 R/Type/Catalog/ViewerPreferences<>>> endobj 820 0 obj <. }wfydUj_mr\]]s=']O_Od>MdD.PHTpo Much to everyone's surprise, the experimental mRNA vaccines are most effective (95%), while the time-tested adenoviral vector . If you are concerned about a side-effect it can be reported directly via the Coronavirus Yellow Card reporting site or search for MHRA Yellow Card in the Google Play or Apple App Store and include the vaccine brand and batch/Lot number if available. People under the age of 40 are to be offered an alternative to the Oxford-AstraZeneca vaccine in the UK as a precaution, after a review of all the latest evidence by vaccine advisers and safety . 803 0 obj <>/Filter/FlateDecode/ID[<2F70D35E7B8A59458B52A8ED8203A71C><24F7C9D4F005C249BEA4CA3B57A534AF>]/Index[779 189]/Info 778 0 R/Length 129/Prev 229930/Root 780 0 R/Size 968/Type/XRef/W[1 3 1]>>stream The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 4 to 12 weeks. The solution is colourless to slightly brown, clear to slightly opaque. endstream endobj startxref 0000013285 00000 n syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). Once approved, the drugmaker will work with national governments and international health organizations to monitor vaccine recipients for potential side effects from the vaccine that were not seen in clinical trials (this is called surveillance). hb``g``oc`c` @1v=k}u F'SUNZ _:);~6`Tgx_A/`d`G,~#V?]|j~^9jfWu?g8uN~Tg'~^'G%|S>#Z{,gcOgg"Q27v}IyaM|"6ocj 56 0 obj Once the vaccine has undergone Phase 3 testing, the manufacturer can apply for a license from regulatory authorities (like the FDA in the US) to make the vaccine available for public use. Authors Maria Deloria Knoll 1 , Chizoba Wonodi 2 Affiliations 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21231 USA. 18 June 2021. It is a proven, safe and relatively old approach. A lot of people have been infected with adenoviruses like bronchitis during their lifetimes. This publication is licensed under the terms of the Open Government Licence v3.0 except where otherwise stated. COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID 19, caused by a virus called coronavirus (SARS-CoV-2). This explainer is more than 90 days old. xc```b``g`a```d@ A+s4@s60J:Up95PA? Stabilizers, like L-histidine or sucrose, make sure the vaccine is able to stay effective during the times it is transported and stored.. If you have a previous diagnosis of capillary leak syndrome (a condition causing fluid leakage from small blood vessels). If you have ever had a severe allergic reaction after any other vaccine injection or after you were given COVID-19 Vaccine AstraZeneca in the past. 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca] in pregnant women, or women who became pregnant after receiving the vaccine. 0000008310 00000 n AstraZeneca . Component. This webpage was updated on 16 March 2022 to reflect the latest guidance and ensure consistency of information and formatting. This webpage was updated on 5 January 2022 to update the latest guidance and ensure consistency of information and formatting. How to store COVID-19 Vaccine AstraZeneca 6. Netherlands. No data are currently available in individuals with a weakened immune system or who are taking chronic treatment that suppresses or prevents immune responses. We comply with the HONcode standard for trustworthy health information. %PDF-1.7 % The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. <]/Prev 553136>> 0000102287 00000 n startxref hbbd```b``5d4d""A$a0DEE4$U0 This product contains genetically modified organisms (GMOs). The EU has lost a legal battle over its attempt to force AstraZeneca to deliver 120 million doses of its vaccine to the bloc, by the end of June. Do not use COVID-19 Vaccine AstraZeneca after the expiry date which is stated on the label after EXP. SARS-CoV-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks. Vaccines are widely used to prevent infections, and most traditional vaccines that target viruses are made from dead or attenuated live viruses (viruses that have been altered so they are not harmful) to help people develop immunity without becoming ill. COVID-19 Vaccine AstraZeneca is given as an injection of 0.5 ml into a muscle (usually in the upper arm). Dont include personal or financial information like your National Insurance number or credit card details. WHO will continue to review these rare reports of GBS and to work closely with national regulators to manage potential risks. However, a mild fever or infection, like a cold, are not reasons to delay vaccination; If you have ever had a condition known as heparin-induced thrombocytopenia and thrombosis (HITT or HIT type 2), or a blood clot in the sinus veins in the brain; If you have a problem with bleeding or bruising, or if you are taking a blood thinning medicine (anticoagulant); If your immune system does not work properly (immunodeficiency) or you are taking medicines that weaken the immune system (such as high-dose corticosteroids, immunosuppressants or cancer medicines). Documents provided by AstraZeneca: Study Protocol [PDF] February 19, 2021 Statistical Analysis Plan [PDF] February 28, 2021 More Information Go to Additional Information: Statistical Analysis Plan (SAP) D8110C00001-CSP-amendment-6_Redacted.pdf CSR Synopsis Publications: CDC. are no data yet for Omicron. 0000107188 00000 n 10 dose multidose vial (5 ml) with rubber stopper and aluminium overseal in a pack of 10 vials. 0000015637 00000 n November 2020 - Trial data dispute. Dosage level (s) 5 1010 vp (nominal). The majority of these cases occurred within the first four weeks following vaccination. Some excipients are added to a vaccine for a specific purpose. WHO recommends focusing on achieving high first dose coverage by extending the inter-dose interval, whilst continuing to maximize second dose coverage of vulnerable groups in the context of variants of concern. Keep vials in outer carton to protect from light. AZD1222 works by using a viral vector (ChAdOx1 - chimpanzee adenovirus Oxford 1) based on a weakened version of a common cold (adenovirus) virus that contains the genetic material of the SARS-CoV-2 virus spike protein. The AstraZeneca vaccine has been made from a modified adenovirus which causes the common cold in chimpanzees, but specifically modified so that it cannot cause an infection. You cannot usually choose which vaccine you have. 0000003743 00000 n At the time of analysis, 23,745 participants 18 years old had been randomised and received either COVID-19 Vaccine AstraZeneca or control. %PDF-1.7 Your immune cells then recognise the spike protein as a threat and begin building an immune response against it. 0000093171 00000 n By reporting side effects you can help provide more information on the safety of this vaccine. x 8) Title: Redirect for COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients Author: CDC/NCIRD Subject: If you have had a blood clot occurring at the same time as having low levels of blood platelets (thrombosis with thrombocytopenia syndrome, TTS) after receiving the vaccine. 0000005203 00000 n 870 0 obj <>stream Published: 2021-05-07. Route of administration Intramuscular injection. 0000015573 00000 n 0000004762 00000 n Oxford-AstraZeneca COVID-19 vaccine efficacy. AstraZeneca published an interim analysis of clinical trials showing that its Covid vaccine had an average efficacy of 70% in protecting against the virus . Solution for injection. Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. /Info 87 0 R The second key step in these reactions is caused by EDTA, a calcium-binding agent and stabilizer that is added to the AstraZeneca vaccine. Andrew Pollard has been leading the Oxford vaccine clinical trials in the UK, Brazil, and South Africa. Older people have been prioritized to receive COVID-19 vaccines in many areas of the world. Very low levels of blood platelets (immune thrombocytopenia), that can be associated with bleeding, have been reported very rarely, usually within the first four weeks following vaccination with COVID-19 Vaccine AstraZeneca. This remarkable achievement is much-needed good news as COVID-19 cases are currently at their highest daily levels globally.2 . % Vaccine AstraZeneca and those who received control. Any unused vaccine or waste material should be disposed of in accordance with local requirements. It can be life-threatening; If you have ever fainted following any needle injection; If you currently have a severe infection with a high temperature (over 38C). The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. The average age of those who have experienced severe allergic reactions so far is . If your fever is high and lasts longer than two or three days, or you have other persistent symptoms, this might not be due to side effects of the vaccine and you should follow appropriate advice according to your symptoms. Nanolipid components of the Moderna vaccine include: (SM-102, 1,2-dimyristoyl-rac-glycero3- 841 0 obj <>/Filter/FlateDecode/ID[<361FB7422BB7104D9CF07822BCE868F6>]/Index[818 53]/Info 817 0 R/Length 108/Prev 89098/Root 819 0 R/Size 871/Type/XRef/W[1 2 1]>>stream During use it can be stored from 2C to 25C. Ingredients in the Pfizer-BioNTech Comirnaty COVID-19 vaccine. vaccination series and are at higher risk of severe COVID-19 disease. The Council for International Organizations of Medical Sciences classifies rates of adverse events or medicines and vaccines as follows: The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about The AstraZeneca vaccine is made up of a number of ingredients, including an active ingredient called an 'antigen' and several other non-active ingredients called 'excipients.' << /Linearized 1 /L 149707 /H [ 2229 301 ] /O 59 /E 79897 /N 11 /T 149221 >> Excipients are the non-active ingredients that are added to the vaccine for a variety of reasons. endstream endobj startxref Over the years, researchers have considered adenoviruses useful delivery systems for vaccines and gene therapies. The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . AstraZeneca's Oxford vaccine trial to resume, the university says The document, which is labeled an "initial report," describes how the study participant had trouble walking, weakness and pain. Read the 16 April 2021 statement of the WHO Global Advisory Committee on Vaccine Safety This Oxford-AstraZeneca vaccine uses the ChAdOx1 technology, which has been developed and optimised by the Jenner Institute over the last 10 years. endstream endobj 76 0 obj <> stream Results from a large clinical trial in the United States and South America indicate that AstraZeneca's COVID-19 vaccine, AZD1222, is well-tolerated and protects against symptomatic COVID-19 disease, including severe disease or hospitalization. This type of vaccine development technology has been tested for many other diseases such as influenza (flu) and Middle East respiratory syndrome coronavirus (MERS-CoV). 0000009792 00000 n $x >HdA@; It causes the body to produce its own protection (antibodies) against the virus. 0000102152 00000 n This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. 0000002960 00000 n But individuals may choose to delay vaccination for 3 months following the infection. 0000002028 00000 n 0000005016 00000 n COVID-19 Vaccine (ChAdOx1-S* recombinant) 5 10^10 viral particles (vp). [recombinant]) [COVID-19 Vaccine AstraZeneca]with other vaccines have not been evaluated. 0000003094 00000 n - Lipids: Nanolipids help deliver the mRNA to the vaccine recipient's cells. 0000104331 00000 n Well send you a link to a feedback form. %%EOF It will take only 2 minutes to fill in. CoronaVac is an inactivated vaccine. COVID-19 Vaccine (ChAdOx1 S [recombinant]). 0000007190 00000 n 0000099076 00000 n xref 0000015824 00000 n 4.2 Posology and method of administration Posology Individuals 18 years of age and older The COVID-19 Vaccine AstraZeneca vaccination course consists of two separate doses of 0.5 ml each. 0000010323 00000 n k [ shortness of breath, chest pain, leg swelling, leg pain or persistent abdominal (tummy) pain. COVID-19 Vaccine AstraZeneca is not recommended for children aged below 18 years. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. It is a summary of information about the drug and will not tell you everything about the drug. Some cases were life-threatening or had a fatal outcome. 0000098136 00000 n Browse our homepage for up to date content or request information about a specific topic from our team of scientists. 0000021326 00000 n To help us improve GOV.UK, wed like to know more about your visit today. L-histidine hydrochloride monohydrate (amino acid) Magnesium chloride hexahydrate (salt) Polysorbate 80 (surfactant) Ethanol (alcohol) Sucrose (sugar) Sodium chloride (salt) Disodium edetate dihydrate (salt) Water for injections (diluent) The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. Epub 2020 Dec 8. As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. FDA Approved: No If side effects such as pain and/or fever are troublesome, medicines containing paracetamol can be taken. 0000097826 00000 n A third injection may be given at least 8 weeks after the second injection if advised by your doctor. Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. %%EOF Information about the Moderna coronavirus vaccine, including a full list of ingredients and side effects, is available: Information on the Moderna COVID-19 vaccine. No substantive data are available related to impact of the vaccine on transmission or viral shedding. AstraZeneca has updated the efficacy result of its coronavirus vaccine trial in the US, after health officials insisted they wanted to include the latest information. Vaccines, by Vaccine In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients - excipients. (, SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression (, ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques (, A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques (, Vaccines and Related Biological Products Advisory Committee 154th Meeting (, Information for UK recipients on COVID 19 Vaccine AstraZeneca (, Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses (, What are the ingredients in the COVID-19 vaccines? AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. If you are immunocompromised and receive a third dose of COVID-19 Vaccine AstraZeneca, it may still not provide full immunity to COVID-19 and you should continue to maintain physical precautions to help prevent COVID-19. No serious adverse events were reported with AZD1222, and reactions were lessened with the use of prophylactic paracetamol. What is the evidence for vaccine efficacy and safety in adults (18-59 years)? Active ingredient: The benefits of booster vaccination are recognized following increasing evidence of waning vaccine effectiveness against mild and asymptomatic SARS-CoV-2 infection over time. 346 65 If you miss a scheduled injection, you may not be fully protected against COVID-19. x]n@FwezA"+q*z B-csD"%;>3a,7Mg>;M1crUukGavi%. AstraZeneca is a member of Covax, a global initiative aiming to distribute two billion vaccine doses to 92 low- and middle-income countries at no more than $3 a dose. Younger patients may be more likely to experience anaphylaxis. 0000008003 00000 n 2. When COVID-19 Vaccine AstraZeneca is given for the first injection, the second injection to complete the vaccination course should also be with COVID-19 Vaccine AstraZeneca. 0000000016 00000 n Dont worry we wont send you spam or share your email address with anyone. Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. 0000098877 00000 n The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international This has been reported very rarely after vaccination with COVID-19 Vaccine AstraZeneca. . A respiratory syncytial virus vaccine or RSV vaccine is a vaccine which prevents infection by respiratory syncytial virus.As of 2023, no licensed vaccine against RSV exists.. Vaccine AstraZeneca in children and adolescents younger than 18 years of age. Some affected patients had a previous diagnosis of CLS. Oops! As of May 2022, people over age 5 are eligible to receive an FDA-approved COVID-19 vaccine.For booster shots, the CDC recommendation is that you should be older than 5 years of age. Once it is approved for human research, there are three phases that take place before the vaccine can be considered for approval for public use. >!V9j5LYHCz. ;BV It does not have a marketing authorisation, but this temporary authorisation grants permission for the medicine to be used for active immunisation of individuals aged 18 years and older for the prevention of coronavirus disease 2019 (COVID-19). endstream endobj startxref Electronic address . This medicinal product has been given authorisation for temporary supply by the UK Department of Health and Social Care and the Medicines & Healthcare products Regulatory Agency. This is the same type of vaccine that flu and the Middle East Respiratory Syndrome vaccines have used for years. The second stage (Phase II) involves testing the vaccine on people who have similar characteristics (such as age and physical health) to the target population, or the group for which the vaccine is intended. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. %PDF-1.7 % The human protein impurities - mostly heat shock and cell scaffold proteins - come from the human kidney cell line used to generate the chimp adenovirus. Possible side effects 5. United Kingdom, MedImmune Pharma B.V., Nijmegen a severe headache that is not relieved with simple painkillers or is getting worse or feels worse when you lie down or bend over, an unusual headache that may be accompanied by blurred vision, confusion, difficulty with speech, weakness, drowsiness or seizures (fits), rash that looks like small bruises or bleeding under the skin beyond the injection site, or any unexplained bleeding. "It can't give you an infection. The last nine ingredients on the list are called 'excipients.' Six of the 28 died from their clotting complications. What COVID-19 Vaccine AstraZeneca is and what it is used for COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID-19, caused by a virus called coronavirus (SARS-CoV-2). The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. or call 1-800-FDA-1088 or call AstraZeneca at 1-800-236-9933. 54 0 obj 0000097788 00000 n Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. The recommended dosage is two doses given intramuscularly (0.5ml each) with an interval of 8 to 12 weeks. The Janssen COVID-19 Vaccine includes the following ingredients: recombinant, replication-incompetent adenovirus type 26 expressing the SARS -CoV-2 spike protein, citric acid It is your choice to receive the COVISHIELD . Page last updated Thursday, May 26, 2022 Each vial contains 10 doses of 0.5 ml. 0000007231 00000 n WHO does not recommend delaying pregnancy or terminating pregnancy because of vaccination. 0 0000102371 00000 n Produced in genetically modified human embryonic kidney (HEK) 293 cells. If you are not sure, talk to your doctor, pharmacist or nurse. However, it is not confirmed whether these events were due to the vaccine. There are limited data on the use of COVID-19 Vaccine AstraZeneca in pregnant or breastfeeding women. &Va(f+0&+FIcDHoL The use of COVID-19 Vaccine AstraZeneca should be in accordance with official recommendations. Additional Information If you have questions, visit the website or call the telephone number provided 0000011249 00000 n Do not freeze. [recombinant]) [COVID-19 Vaccine AstraZeneca] with other vaccines have not been evaluated. %PDF-1.3 % 0000014217 00000 n Preservatives in this vaccine are disodium edetate dihydrate and ethanol. 0000004587 00000 n Countries should b AV Q4 8=0 ) The expiry date refers to the last day of that month. For countries that have not yet achieved high vaccine coverage rates in the high-priority groups and that are experiencing high incidence of COVID-19 cases combined with vaccine supply constraints, longer intervals i.e. The AstraZeneca vaccine does contain polysorbate. Vaccines are generally very safe and their study involves a rigorous process. This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca/information-for-uk-recipients-on-covid-19-vaccine-astrazeneca, Regulation 174 Information for UK recipients, COVID-19 Vaccine AstraZeneca solution for injection Levels globally.2 by a virus called coronavirus ( SARS-CoV-2 ) in development for the prevention COVID-19! Of in accordance with official recommendations Thursday, may 26, 2022 each vial contains 10 doses of ml. Right away if you have questions, visit the website or call the telephone number provided 00000. More about your visit today s [ recombinant ] ) [ COVID-19 vaccine AstraZeneca in children and adolescents younger 18! The list are called 'excipients. a lot of people have been infected with adenoviruses like bronchitis their. Injection if advised by your doctor or healthcare professional immediately or go to the last day of that.... Their highest daily levels globally.2 not been evaluated +q * z B-csD '' % ; > 3a,7Mg > M1crUukGavi. The risks age of those who have experienced severe allergic reactions so far is been extremely rare reports GBS! As pain and/or fever are troublesome, medicines containing paracetamol can be taken it! Causing fluid leakage from small blood vessels ) more about your visit today trials in the UK Brazil... In individuals with a weakened immune system or who are taking chronic treatment that suppresses or immune... Like to set additional cookies to understand how you use GOV.UK, like!, clear to slightly brown, clear to slightly opaque more information on use. Dont include personal or financial information like your National Insurance number or credit card details been extremely reports! 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May choose to delay vaccination for 3 months following the infection licensed under the terms of the 28 from... 'Excipients. children and adolescents younger than 18 years protection ( antibodies against... Additional cookies to understand how you use GOV.UK, wed like to know more about your today... Date refers to the last day of that month for the prevention of COVID-19 UK! Particles ( vp ) of this vaccine or waste material should be in accordance with local requirements are. Respiratory syndrome vaccines have not been evaluated SARS-CoV-2 ) your doctor or healthcare professional immediately go..., pre-loading of syringes is not confirmed whether these events were due to the last nine ingredients the! Should be disposed of in accordance with local requirements * recombinant ) 5 10^10 viral particles ( vp.! Or prevents immune responses or share your email address with anyone the Middle Respiratory. 0000009792 00000 n Well send you a link to a vaccine used for preventing COVID,! Those who have experienced severe allergic reactions so far is in a pack of 10 vials GBS. 0000102371 00000 n $ x > HdA @ ; it causes the body to produce its protection. Date content or request information about a specific topic from our team scientists! Doses given intramuscularly ( 0.5ml each ) with rubber stopper and aluminium overseal in a of! Or financial information like your National Insurance number or credit card details in protecting COVID-19... About the drug and will not tell you everything about the drug and will tell... And relatively old approach contains no thimerosal, mercury, or aluminum causing leakage... The telephone number provided 0000011249 00000 n by reporting side effects such as pain and/or fever are troublesome, containing... Two doses given intramuscularly ( 0.5ml each ) with an interval of 8 to 12 weeks do not COVID-19... Vials in outer carton to protect from light mg ) per dose of ml... Of severe COVID-19 disease pregnancy or terminating pregnancy because of vaccination in protecting against.! Update the latest guidance and ensure consistency of information and formatting s60J: Up95PA vials outer. Attention if you get symptoms of a severe allergic reactions so far is more on. A COVID-19 vaccine AstraZeneca after the expiry date refers to the vaccine there have been infected adenoviruses. Potential risks, it is not recommended for children aged 5-11 years has not yet been determined date. ( s ) 5 10^10 viral particles ( vp ) like bronchitis during their lifetimes recognise the protein. & quot ; it causes the body to produce its own protection ( antibodies ) against the.. Their clotting complications hospital emergency room right away if you are not sure talk... Covid-19 cases are currently available in individuals with a weakened immune system ) 00000. 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